Replacing Magic Bullets With Beneficial Pleiotropy in Atherosclerosis

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Replacing Magic Bullets With Beneficial Pleiotropy in Atherosclerosis.

Theories of atherogenesis have evolved over the decades, with established concepts often being incorporated into new theories. This is the natural progression of science; the old theories are not necessarily discredited—in many cases, they explained what was known at the time—but rather new models emerge that incorporate new knowledge and change the emphasis placed on particular processes. Thus...

متن کامل

Stapled peptides: Magic bullets in nature's arsenal.

inhibitor of Mcl-1. Stewart et al. screened a library of stapled peptides based on the BH3 domains of BCL-2 family proteins (library depicted on left) and identified a selective inhibitor of MCL-1 (structure of the inhibitor in complex with Mcl-1 shown on the right), one of the anti-apoptotic family members that plays a key role in the survival of cancer cells. The peptide inhibitor, derived fr...

متن کامل

Radioimmunotherapy of Non-Hodgkin’s Lymphoma: From the ‘Magic Bullets’ to ‘Radioactive Magic Bullets’

Radioimmunotherapy (RIT) of lymphoma with Zevalin and Bexxar was approved by FDA in 2002 and 2003, respectively, for the treatment of relapsed or refractory CD20+ follicular B-cell non-Hodgkin´s lymphoma. In 2009, Zevalin was also approved for consolidation therapy in patients with follicular non-Hodgkin's lymphoma that achieve a partial or complete response to first-line chemotherapy. For foll...

متن کامل

Small non-coding RNAs as magic bullets.

RNA interference (RNAi) - inhibition of gene expression by small, non-coding RNAs [small interfering RNAs (siRNAs) or microRNAs (miRNAs)] - has changed our view of regulation of expression dramatically. The application of siRNAs for both functional analysis of genes and medication raises several questions. These include the design of the double-stranded oligonucleotides, their preparation and i...

متن کامل

Immunoconjugates : " Magic Bullets " for Cancer Therapy ?

Conjugating cytotoxic agents to antibodies allows for site-specific delivery of the agent to tumor cells and should provide increased efficacy and reduced non-specific toxicity. These site-specific cpotogc agents are known as irnmunoconjugates or "magic bullets" and have demonstrated great promise as therapeutic agents for cancer and other diseases. The historical developments and future potent...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Circulation Research

سال: 2016

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.116.309934